Anti-phospholipid antibody syndrome (APS, APAS, anti-cardiolipin syndrome, Hughes syndrome) is an autoimmune disease, which includes clinical symptoms such as arterial and venous thrombosis, thrombocytopenia and recurrent fetal loss.

Primary and secondary forms of APAS can be distinguished. In the primary form of APAS, antibodies against phospholipids are formed without any underlying disease presence. In the secondary form of APAS, the symptoms are associated with other autoimmune diseases, particularly systemic lupus erythematosus (SLE).

Traditionally, laboratory diagnosis of APAS has been based on the study of antibodies against cardiolipin and ß2-glycoprotein I. Where these tests give a negative result, the determination of other antibodies provides an alternative diagnosis method. In addition, specific antibody profiles are associated with clinical complications associated with APAS, and may allow the differentiation between asymptomatic antibody carriers.

LINE Immunoassay for 27 Food Allergens

Allergies and food intolerances are steadily increasing in our culture over the past 30 years. Early, accurate and professional diagnosis may relieve affected people enormously.

The sIgG4 Allergy LINE 1 assay (27 allergens) is the ideal solution for a reliable and fast result in the determination of allergen-specific sIgG4 antibodies in patients with suspected food intolerances.

More and more people suffer from symptoms after consuming certain foods - commonly referred to as food incompatibility or intolerance. Bloating, headache, fatigue, diarrhea or irritable bowel indicate, among other gastroenterological and dermatological symptoms, a possible food intolerance. Symptoms can occur within hours or even several days after the food intake. This makes it difficult for the health professional and the patient to identify the food responsible for the incompatibility. Using our LINE assay, which can detect sIgG4 antibodies to certain food allergens, the physician can develop therapeutic options (for example, a 1- or 2-month elimination diet) to relieve the patient's symptoms.

LINE Immunoassay for 27 Inhalation Allergens

Allergies and food intolerances are steadily increasing in our culture over the past 30 years. Early, accurate and professional diagnosis may relieve affected people enormously.

The sIgE Allergy LINE 1 assay (27 allergens) is the ideal solution for a reliable and fast result in the determination of allergen-specific IgE antibodies in patients with suspected inhalation allergies with different clinical symptoms:

• Seasonal and perennial rhinitis and conjunctivitis
• Allergic asthma
• Allergic eczema
• allergic gastrointestinal diseases

This kind of allergy diagnosis has been developed for professional groups like physicians, allergists and non medical practitioners who seek a fast, reliable, jointly solution in direct communication with patients. Different situations or patient-specific conditions could make conventional skin test methods (prick test) partially impossible or difficult to be carried out. Thus in-vitro testing should be preferred for example instead of a skin test, at least in pregnant women, in children, or in patients with acute skin problems, respectively. However this possibility of diagnosis should be mentioned to the patient in general.

Analysis of peripheral polyneuropathies with immunodot

Inflammatory neuropathies of the peripheral nervous system are characterized by numerous clinical symptoms, which can range from mild fatigue and uncharacteristic discomfort to neuromuscular disorders and functional deficiencies, like respiratory failure and cardiac arrest.

Autoantibodies against gangliosides occur in autoimmune diseases of the peripheral nervous system. Gangliosides are acidic glycolipids, comprised of a lipid (ceramide), an oligosaccharide chain and sialic acid.

Gangliosides are components of cell membranes and are particularly found in the central and peripheral nervous system.

These antibodies directly cause an inflammation or demyelinization of the myelin sheaths, therapy of autoimmune neuropathies is therefore based on immunoregulation.

This means that an accurate diagnosis is crucial for initiation of therapy.

Request More Info